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Mental Disorders, Mental Illness and the Family Court: A Reference Guide for Non-Medical Professionals

為了解決hm的問題，作者Rutherford, Joan,Cross, Jennifer,Tolan, Stephanie 這樣論述：

Dr Joan Rutherford FRCPsychJoan became Chief Medical Member, First Tier Tribunal (Mental Health) in 2010, and is also an honorary consultant at South London and Maudsley NHS Foundation Trust. Her post combines the position of doctor at the Mental Health Tribunal with a management and training role a

nd she is a member of the tribunal’s child and adolescent mental health services panel (CAMHS). Previously, she was a consultant psychiatrist at Surrey and Borders Partnership NHS Foundation Trust from 1992-99, then at South West London and St George’s Mental Health NHS Trust from 1999-2010. Joan co

-authored the eBook Mental Disorders -Information for Mental Health Tribunal Members, which was made available to all judicial members of HM Courts and Tribunals Service in August 2019. Judge Meleri TudurShe is the Deputy President of the Health Education and Social Care Chamber of the First-tier Tr

ibunal; responsible for the Special Educational Needs and Disability, Care Standards and Primary Health Lists Jurisdiction within that Chamber. She has experience of Family Court work. Jennifer Cross JP CQSWJenny worked for many years as a social worker/manager and approved mental health professiona

l (AMHP) for an Inner London borough. She has professional experience in a variety of services including children and families, fostering and adoption, and adult services encompassing mental health. She has also been an academic tutor and practice assessor in the education and training of social wor

kers and AMHPs. Jenny is a longstanding member of the Mental Health Tribunal and a member of the tribunal’s CAMHS panel, the Care Standards Tribunal and the Upper Administrative Tribunal. She sat as a magistrate for 25 years, including in the Family Court, and has been a trustee of several mental he

alth charities. Dr Stephanie Tolan MRCPCHStephanie is a paediatric registrar in the North Central and East London Foundation School training scheme. She obtained an MA in Medical Ethics and Law from Kings College London in 2020, and is now a trainee member of the Ethics Committee at North Middlesex

University Hospital NHS Trust. An active member of the London School of Paediatrics trainees’ committee, Stephanie has a key role in their mentor system - The Paediatric Family - to support trainees throughout their training in London. Dr Andy Cohen MRCPsychAndy is a consultant child and adolescent

psychiatrist at South West London and St George’s Mental Health NHS Trust. He has worked in the field of child and adolescent mental health for over 20 years, the last 15 based in a busy community team in South West London. Andy has an interest in medical education and is the Programme Director for

higher specialist training in child and adolescent psychiatry on the St George’s trainee scheme.

hm進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決hm的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

A Year in Flowers: Inspiration for Everyday Living

為了解決hm的問題，作者Connolly, Shane 這樣論述：

Shane Connolly has been creating timeless, artisanal floral decorations for over twenty years. He has built an enviable reputation worldwide with his small, dedicated team at his studio in Notting Hill, London. He holds Royal Warrants of Appointment to both HM the Queen and HRH the Prince of Wales.

Shane will only work with seasonal and local flowers, replanting after use where possible. He lectures and gives masterclasses at leading flower schools all over the world, and runs several masterclasses of his own in London.

以微波萃取愛玉殼果膠探討其理化特性與抗氧化活性

為了解決hm的問題，作者盧詩婷 這樣論述：

愛玉為台灣的特有種植物富含果膠及抗氧化成分，屬高經濟價值之作物。經統計愛玉全台產量將近 555 公噸，然而愛玉加工副產物－愛玉殼大多數並沒有被有效利用。因此本研究將以不同微波萃取條件 (微波功率 300 - 800 W、萃取時間 3 - 4 分鐘與 0 - 200 mM檸檬酸濃度萃取溶液) 萃取愛玉殼果膠，並探討其產率、半乳糖醛酸含量、酯化度、分子量、官能基特性與抗氧化活性。結果發現產率會隨著檸檬酸濃度與微波功率之增加而上升，並在 200 mM 檸檬酸與微波功率 800 W與萃取時間 4分鐘條件下有最高果膠產率 (21.6 ± 0.1% ) 。半乳糖醛酸含量會隨著檸檬酸濃度增加反而隨之下降。

酯化度也會隨檸檬酸濃度增加而下降，所有萃取條件下果膠之酯化度皆大於 50% 屬於高甲氧基果膠。此外在抗氧化能力方面發現愛玉殼果膠DPPH自由基清除率的IC50為175.1 μg/mL，還原力則隨著果膠濃度增加，果膠之還原力有增加的趨勢。綜合以上研究結果發現愛玉殼果膠具有開發功能性保健食品之潛力。關鍵字：果膠、愛玉殼、微波輔助萃取、半乳糖醛酸、酯化度、傅立葉轉換紅外線、2,2 - 二苯基 - 1 - 三硝基苯肼自由基清除率、還原力