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國立臺灣科技大學 化學工程系 張家耀所指導 諾菲的 多功能環保量子點作為靶向雙成像和光動力癌症治療平台 (2021),提出Ultra boost 21 PTT關鍵因素是什麼,來自於carbon quantum dots、Mn dopant、MRI、photodynamic therapy、photoluminescence。

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多功能環保量子點作為靶向雙成像和光動力癌症治療平台

為了解決Ultra boost 21 PTT的問題,作者諾菲 這樣論述:

Recommendation letter iiAbstract in chinese iiiAbstract in english vAcknowledgments viiContents viiiList of figures xiiList of tables xviiList of abbreviation ixChapter 1. Introduction 11.1 General introduction 21.2 Objective of study 61.3 Structure of the dissert

ation 6Chapter 2. Literature review 82.1 Nanoparticles 92.2 Semiconductor quantum dots 102.3 The quantum confinement, optical properties, and core/shell structure of QDs 122.4 Synthesis of QDs 192.4.1 Nucleation and growth 212.4.2 Hot injection method 252.4.3 Heat-up method

282.4.4 Solvothermal approach 312.4.5 Hydrothermal approach 332.4.6 Microwave irradiation approach 352.5. Folate receptor targeting agents 382.6 QDs biomedical applications 422.6.1 Optical imaging 422.6.2 Magnetic resonance imaging (MRI) 442.6.3 Drug delivery 462.6.4 Photo

‑dynamic therapy (PDT) and Photo‑thermal (PTT) therapy 59Chapter 3. Manganese-doped green tea-derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform 483.1 Introduction 523.2 Experimental methods 533.2.1 Materials 553.2.2 Synthesis of Mn-CQD 563.2.

3 Preparation of Mn-CQDs@FA/Ce6 563.2.4 Characterization 573.2.5 Cell structure and viability evaluation 583.2.6 In vitro photodynamic cancer cells’ ablation 593.2.7 Cell imaging 603.3 Results 603.3.1 Synthesis of Mn-CQDs 603.3.2 Preparation of Mn-CQDs@FA/Ce6 643.3.3 Photolu

minescence characteristics and ROS generation of Mn-CQDs@FA/Ce6 conjugates 663.3.4 Mn-CQDs as MRI contrast agents 693.3.5 In vitro cellular uptake and therapeutic effect 723.4 Discussion 753.5 Summary 77Chapter 4. Multifunctional MnCuInSe/ZnS quantum dots for bioimaging and photodyna

mic therapy 794.1 Introduction 804.2 Experimental methods 834.2.1 Materials 834.2.2 Synthesis of the CuInS, CuInSe, MnCuInSe core and CuInS/ZnS, CuInSe/ZnS and MnCuInSe/ZnS core/shell carbon quantum dots 844.2.3 Characterization 854.2.4 Optical and photoluminescence properties of

MnCuInSe/ZnS assay 854.2.5 Photoactivity assessment of MnCuInSe/ZnS 864.2.6 In Vitro MR 864.2.7 Cell culture and in vitro cytotoxicity evaluation 874.2.8 Cell imaging 884.3. Results and discussion 884.3.1. Synthesis and characterization of MnCuInSe/ZnS 884.3.2 Optical and photol

uminescence properties of MnCuInSe/ZnS 904.3.3 Stability of MnCuInSe/ZnS QDs colloidal solution 944.3.4 ROS generation of MnCuInSe/ZnS 974.3.5 Magnetic resonance imaging 984.3.6 In vitro cellular uptake and therapeutic effect 1014.3.7 Confocal imaging 1024.4. Summary 105Chapte

r 5. Conclusions 1065.1 Conclusions 1075.2 Future outlooks 109References 110Appendix 134