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End Game: Does Israel Have a Plan?

為了解決Part Time的問題，作者Sachs, Natan 這樣論述：

How Israelis envision and plan for the future of their countryDoes Israel have a plan? What does the country want to look like in 10 or 20 years? What borders does it hope to have? Will the West Bank or the Gaza Strip be part of it? Will the Palestinians residing the territories be granted citizensh

ip and become Israeli citizens? Does the country as a whole even know what it wants, what its goals are, or how to achieve them?Israel faces a fundamental question, a "trilemma." It can choose only two of three different goals many Israelis hold dear: to maintain control over the West Bank, with its

strategic and religious significance to Israel; to retain a clear Jewish majority, the goal of the Zionist movement that founded the state; or to remain a democracy, with full voting rights for all citizens.This trilemma has caused world leaders and publics, Israel-supporters and critics, to wonder

aloud time and again: what does Israel want? If it wishes to maintain its Jewish and democratic character, surely it must separate from the West Bank and its population; why then does Israel keep building in Israeli settlements in the West Bank, making such separation all the more difficult? And if

it plans to retain control over the West Bank, is it really willing to give up on either its Jewish nature or its democracy?End Game attempts to solve the puzzle of why the Israeli strategic vision seems so elusive to many foreigners and Israelis alike. It explores how Israelis' beliefs about their

future are formed and how their visions are translated into policy, focusing on three factors in depth: the role of security concerns, ideology, and domestic political constraints that combine to shape Israel's strategic posture.The book contrasts the full range of views in Israel over the future o

f the West Bank, from supporters of a bi-national state or confederacy on the left, to supporters of a "one state" on the far right of the political spectrum. It pays particular attention to the worldview of the political center-right, led by Prime Minister Benjamin Netanyahu, a conservative, risk-a

verse and "anti-solutionist" approach to the problem. This worldview, following decades of precedent, rejects the need for a full-fledged strategic "solution" to the problem, leading to widespread confusion over Israel's goals. The book analyses and critiques this approach, arguing forcefully for en

ding Israeli indecision over the future of the land and in favor of partition and, eventually, peace. Dr. Natan Sachs is a fellow in the Center for Middle East Policy at the Brookings Institution. His research focuses on Israel’s foreign policy, its domestic politics, and on U.S.-Israeli relations

. Before joining Brookings, Sachs was a Hewlett Fellow at Stanford’s Center on Democracy, Development and the Rule of Law, a Fulbright Fellow in Indonesia, and a Visiting Fellow at Tel Aviv University’s Dayan Center for Middle Eastern and African Studies.

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照顧者對於育兒APP使用經驗及滿意度之研究

為了解決Part Time的問題，作者張可橙 這樣論述：

自2020年COVID-19疫情延燒至今，對家庭帶來很大的生活改變，其中除了育兒日常之外，在防疫期間家庭互動型態也正悄悄地改變。因此，為了解家長育兒實際需求以及使用相關資源是重要的趨勢。家有嬰幼兒的父母需要紀錄各種嬰幼兒的生活紀錄，以確保嬰幼兒的健康狀況及健康檢查，如何善用各項育兒資源，將嬰兒照護資訊化，家長可以即時了解子女目前的狀況。隨著資訊科技進步，智慧型手機的流行，數位工具也愈來愈行動化及便利性，因此針對嬰幼兒各項活動的APP也蓬勃發展。目前市場上育兒APP種類眾多，但深入探討實際使用與功能是否滿足照顧者需求的研究較少。為了解照顧者對於使用育兒APP相關經驗及滿意度為何？研究首先依據文

獻探討嬰幼兒相關文獻，了解行動裝置在嬰幼兒保育相關之領域應用，再將市面上手持行動裝置平台皆有上架的育兒APP，將各個的功能做比較與統整，以問卷調查方式了解照顧者對於育兒APP實際使用情形以及滿意度。本研究採用科技接受模式為研究架構，加入受試者背景變項探討各構面關係，利用SPSS統計分析方法來驗證各項研究假設。研究結果如下：探討照顧者對於育兒APP的使用經驗之現況與差異。「認知有用性」及「認知易用性」會影響「使用意願」；「使用意願」會影響「滿意度」。根據研究結論，提出相對應研究建議，供未來建置應用程式系統可以擴充功能參考，讓使用者滿意度更加提升。

Civic Ritual, Commemoration and Public Celebration in Urban Britain, 1850-1950

為了解決Part Time的問題，作者Roberts, Ben 這樣論述：

Ben Roberts is Part-Time Lecturer at Teesside University, UK.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Part Time的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.