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臺灣野生酵母菌之族群遺傳基因體學

為了解決DT Beauty的問題，作者李佳燁 這樣論述：

Population genetics is the study of genetic variations within and between groups of individuals. With a long history of domestication, the budding yeast Saccharomyces cerevisiae is a great model for population, ecology and evolutionary studies, given that more than a thousand isolates have been col

lected from a wide range including both artificial and natural niches. Previous studies pointed to East Asia as the geographical origin of the species, where highly genetically diverse wild populations were discovered. Among them, three isolates from Taiwan revealed unprecedented divergence to popul

ations from the rest of the world. However, a lack of systemic survey and isolation in Taiwan limits our knowledge of the species’ distribution and diversity in nature. In the following chapters, I describe the fundamental ideas behind population genetic approach, strategies to sample broadly, and f

indings from the 121 isolates collected in Taiwan. Overall, S. cerevisiae is prevalent in diverse habitats in low abundance, contrary to their dominance in domesticated environments. Multiple coexisting and admixing natural lineages elevated the total genetic diversity within limited geographical ra

nge, comparable to that of continent level. These distinct lineages diverged from Chinese counterparts during the Pleistocene epoch when land bridges connected both regions. Polymorphism pattern within each lineage indicated that the diversity was shaped by differences in life history and selective

pressure. These findings establish the budding yeast harbors rich diversities that provide insights into its natural history.Keywords: population genomics, Saccharomyces cerevisiae, microbial ecology, amplicon sequence